Research Group on Reproductive Medicine

Reproductive Medicine Area

Our activity predominantly involves research in the field of Reproductive Medicine and women’s healt, with a particular focus on factors that cause infertility, and other gynecological and obstetric pathologies

One of our aims is the characterization at single cell resolution of the human uterus, that will provide unprecedented insight at transcriptomic, genomic and spatial changes of this important female organ not only throughout the menstrual cycle but also across lifespan. The comparison in healthy and diseased conditions are also in the scope

Coordinator
Dr. Carlos Simón Vallés
carlos.simon@uv.es; csimon@fundacioncarlossimon.com

RESEARCHERS
Leading, R4

Carlos Simón Vallés    

Established, R3
Recognised/Emerging, R2

Inmaculada Moreno Gimeno
Aymara Mas Perucho    
Tamara Garrido Gómez
Beatriz Rosón Burgo
Ghjuvan Grimaud
María Cristina Carbajo García
María Teresa Cordero Cucart
Nerea Castillo Marco
Sara López Martínez
Stuart P. Atkinson
Xavier Santamaría Costa

First Stage, R1

Bruno Tosón
Irene Muñoz Blat
José Pascual Serrano Serrano
Marta González Monfort
Paula Punzón Jiménez

STAFF
Collaborating Researchers
Nurse
Technicians

María Lloret Pérez
Alba Vives Gómez
Esther Lara Cuesta
Esther Tercero Atencia
Jaime Llera Oyola
Yolanda Castelló Martínez

Administrative assistant

Jaime Herrero Hernández

Publications
Effect of aging on the human myometrium at single-cell resolution. Punzon-Jimenez P, Machado-Lopez A, Perez-Moraga R, Llera-Oyola J, Grases D, Galvez-Viedma M, Sibai M, Satorres-Perez E, Lopez-Agullo S, Badenes R, Ferrer-Gomez C, Porta-Pardo E, Roson B, Simon C, Mas A. Nature Communications. 2024 Jan 31;15(1):945. doi: 10.1038/s41467-024-45143-z. PMID: 38296945

Normothermic machine perfusion systems: where do we go from here?. Lopez-Martinez S, Simon C, Santamaria X. Transplantation. 2024 Jan 1;108(1):22-44. doi: 10.1097/TP.0000000000004573. PMID: 37026713

The role of microRNAs in understanding sex-based differences in Alzheimer’s disease. Llera-Oyola J, Carceller H, Andreu Z, Hidalgo M, Soler-Sáez I, Gordillo F, Gómez-Cabañes B, Roson B, de la Iglesia-vayá M, Mancuso R, Guerini F, Mizokami A, García-García F. Biology of Sex Differences. 2024 Jan 31;15(1):13. doi: 10.1186/s13293-024-00588-1. PMID: 38297404

A cell abundance analysis based on efficient PAM clustering for a better understanding of the dynamics of endometrial remodelling. Domingo J, Kutsyr-Kolesnyk O, Leon T, Perez-Moraga R, Ayala G, Roson B. BMC Bioinformatics. 2023 Nov 22;24(1):440. doi: 10.1186/s12859-023-05569-6. PMID: 37990148

Decoding the endometrial niche of Asherman’s Syndrome at single-cell resolution. Santamaria X, Roson B, Perez-Moraga R, Venkatesan N, Pardo-Figuerez M, Gonzalez-Fernandez J, Llera-Oyola J, Fernandez E, Moreno I, Salumets A, Vankelecom H, Vilella F, Simon C. Nature Communications. 2023 Sep 21;14(1):5890. doi: 10.1038/s41467-023-41656-1. PMID: 37735465

Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids. Yang Q, Ali M, Trevino L, Mas A, Al-Hendy A. Cellular and Molecular Life Sciences. 2023 Aug 31;80(9):274. doi: 10.1007/s00018-023-04919-0. PMID: 37650943

Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function. Mortlock S, Houshdaran S, Kosti I, Rahmioglu N, Nezhat C, Vitonis A, Andrews S, Grosjean P, Paranjpe M, Horne A, Jacoby A, Lager J, Opoku-Anane J, Vo K, Manvelyan E, Sen S, Ghukasyan Z, Collins F, Santamaria X, Saunders P, Kober K, McRae A, Terry K, Vallvé-Juanico J, Becker C, Rogers P, Irwin J, Zondervan K, Montgomery G, Missmer S, Sirota M, Giudice L. Communications Biology. 2023 Aug 16;6(1):780. doi: 10.1038/s42003-023-05070-z. PMID: 37587191

Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation. Segura-Benítez M, Bas-Rivas A, Juárez-Barber E, Carbajo-García M, Faus A, De Los Santos M, Pellicer A, Ferrero H. Human Reproduction. 2023 Aug 1;38(8):1547-1559. doi: 10.1093/humrep/dead138. PMID: 37407281

Human embryo live imaging reveals nuclear DNA shedding during blastocyst expansion and biopsy. Domingo-Muelas A, Skory RM, Moverley AA, Ardestani G, Pomp O, Rubio C, Tetlak P, Hernandez B, Rhon-Calderon EA, Navarro-Sanchez L, Garcia-Pascual CM, Bissiere S, Bartolomei MS, Sakkas D, Simon C, Plachta N. Cell. 2023 Jul 20;186(15):3166-3181.e18. doi: 10.1016/j.cell.2023.06.003. PMID: 37413989

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses. Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez Almazan J, Blesa Jarque D, Miravet Valenciano J, Rubio C, Simon C, Capalbo A. Human Reproduction. 2023 Apr 3;38(4):762-775. doi: 10.1093/humrep/dead033. PMID: 36824049

Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest. Hernandez Mora JR, Buhigas C, Clark S, Del Gallego Bonilla R, Daskeviciute D, Monteagudo-Sanchez A, Poo-Llanillo ME, Medrano JV, Simon C, Meseguer M, Kelsey G, Monk D. Cell Reports. 2023 Feb 9;42(2):112100. doi: 10.1016/j.celrep.2023.112100. PMID: 36763500

The human periconceptional maternal-embryonic space in health and disease. Moreno I, Capalbo A, Mas A, Garrido-Gomez T, Roson B, Poli M, Dimitriadis E, Santamaria X, Vilella F, Simon C. Physiological Reviews. 2023 Jul 1;103(3):1965-2038. doi: 10.1152/physrev.00050.2021. PMID: 36796099

The role of extracellular vesicles in intercellular communication in human reproduction. Gonzalez Fernandez J, Moncayo Arlandi J, Ochando A, Simon C, Vilella F. Clinical Science. 2023 Feb 14;137(3):281-301. doi: 10.1042/CS20220793. PMID: 36762584

The use of copy number loads to designate mosaicism in blastocyst stage PGT-A cycles: fewer is better. Girardi L, Figliuzzi M, Poli M, Serdarogullari M, Patassini C, Caroselli S, Pergher I, Cogo F, Coban O, Boynukalin F, Bahceci M, Navarro R, Rubio C, Findikli N, Simon C, Capalbo A. Human Reproduction. 2023 May 2;38(5):982-991. doi: 10.1093/humrep/dead049. PMID: 36928183

Two studies in the same center, on the same patient population and topic, but with different results. Is the experimental design to blame?. Simon C, Ruiz-Alonso M, Gomez C, Valbuena D. Fertility and Sterility. 2023 Mar;119(3):514-515. doi: 10.1016/j.fertnstert.2022.11.019. PMID: 36462548

Updates on preimplantation embryo research. Bissiere S, Hernandez B, Rubio C, Simon C, Plachta N. Fertility and Sterility. 2023 Sep;120(3 Pt 1):467-472. doi: 10.1016/j.fertnstert.2023.04.039. PMID: 37150393

Uterine leiomyoma with RAD51B:NUDT3 fusion: a report of 2 cases. Dundr P, Machado-Lopez A, Mas A, Veckova Z, Mara M, Richtarova A, Matej R, Struzinska I, Bartu M, Nemejcova K, Dvorak J, Hojny J. Virchows Archiv. 2023 Jul 19. doi: 10.1007/s00428-023-03603-9. PMID: 37466765

Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period. Bolumar D, Moncayo-Arlandi J, Gonzalez-Fernandez J, Ochando A, Moreno I, Monteagudo-Sanchez A, Marin C, Diez A, Fabra P, Checa M, Espinos J, Gardner D, Simon C, Vilella F. eLife. 2023 Dec 27:12:RP88008. doi: 10.7554/eLife.88008. PMID: 38149847

Avoid mixing apples and oranges: blastocysts diagnosed with uniform whole chromosome aneuploidies are reproductively incompetent and their transfer is harmful. Capalbo A, Cimadomo D, Rienzi L, Garcia-Velasco J, Simon C, Ubaldi F. Human Reproduction. 2022 Aug 25;37(9):2213-2214. doi: 10.1093/humrep/deac149. PMID: 35796677

Cell-free fetal DNA testing performance and fetal fraction estimation are not affected in ART-conceived pregnancies. Balaguer N, Mateu-Brull E, Gomez-Lopez M, Simon C, Milan M. Human Reproduction. 2022 Nov 24;37(12):2743-2756. doi: 10.1093/humrep/deac217. PMID: 36223600

Decidualization resistance in the origin of preeclampsia. Garrido Gomez T, Castillo Marco N, Cordero T, Simon Valles C. American Journal of Obstetrics and Gynecology. 2022 Feb;226(2S):S886-S894. doi: 10.1016/j.ajog.2020.09.039. PMID: 33007270

Deciphering the potential coding of human cytomegalovirus: new predicted transmembrane proteome. Mancebo F, Parras-Molto M, Garcia-Rios E, Perez-Romero P. International Journal of Molecular Sciences. 2022 Mar 2;23(5):2768. doi: 10.3390/ijms23052768. PMID: 35269907

Do clinical outcomes differ for day-5 versus day-6 single embryo transfers controlled for endometrial factor?. Stankewicz T, Ruiz Alonso M, Soler Ibanez M, Simon C, Valbuena D. Reproductive Biomedicine Online. 2022 Mar;44(3):478-485. doi: 10.1016/j.rbmo.2021.11.010. PMID: 35125295

Endometrial factor testing is a useful tool in clinical infertility management. Simon C. Reproductive Biomedicine Online. 2022 Jun;44(6):953-960. doi: 10.1016/j.rbmo.2021.12.014. PMID: 35221254

Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Moreno I, Garcia-Grau I, Perez-Villaroya D, Gonzalez-Monfort M, Bahceci M, Barrionuevo MJ, Taguchi S, Puente E, Dimattina M, Lim MW, Meneghini G, Aubuchon M, Leondires M, Izquierdo A, Perez-Olgiati M, Chavez A, Seethram K, Bau D, Gomez C, Valbuena D, Vilella F, Simon C. Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w. PMID: 34980280

Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Diaz-Garcia C, Herraiz S, Pamplona L, Subira J, Soriano M, Simon C, Seli E, Pellicer A. Fertility and Sterility. 2022 Apr;117(4):747-755. doi: 10.1016/j.fertnstert.2021.12.034. PMID: 35367015

Human endometrial cell-type-specific RNA sequencing provides new insights into the embryo-endometrium interplay. Koel M, Krjutskov K, Saare M, Samuel K, Lubenets D, Katayama S, Einarsdottir E, Vargas E, Sola-Leyva A, Lalitkumar P, Gemzell-Danielsson K, Blesa D, Simon C, Lanner F, Kere J, Salumets A, Altmae S. Human Reproduction Open. 2022 Oct 13;2022(4):hoac043. doi: 10.1093/hropen/hoac043. PMID: 36339249

Individual participant data meta-analysis of trials comparing frozen versus fresh embryo transfer strategy (INFORM): a protocol. Wang R, McLernon D, Lai S, Showell M, Chen Z, Wei D, Legro R, Wang Z, Sun Y, Wu K, Vuong L, Hardy P, Pinborg A, Stormlund S, Santamaria X, Simon C, Blockeel C, Mol F, Ferraretti A, Shapiro B, Garner F, Li R, Venetis C, Mol B, Bhattacharya S, Maheshwari A. BMJ Open. 2022 Jul 18;12(7):e062578. doi: 10.1136/bmjopen-2022-062578. PMID: 35851030

Integrative genomic and transcriptomic profiling reveals a differential molecular signature in uterine leiomyoma versus leiomyosarcoma. Machado Lopez A, Alonso R, Lago V, Jimenez Almazan J, Garcia M, Monleon J, Lopez S, Barcelo F, Torroba A, Ortiz S, Domingo S, Simon C, Mas A. International Journal of Molecular Sciences. 2022 Feb 16;23(4):2190. doi: 10.3390/ijms23042190. PMID: 35216305

Lactoferrin modulates gut microbiota and Toll-like receptors (TLRs) in mice with dysbiosis induced by antibiotics. Belles A, Aguirre-Ramirez D, Abad I, Parras-Molto M, Sanchez L, Grasa L. Food & Function. 2022 May 23;13(10):5854-5869. doi: 10.1039/d2fo00287f. PMID: 35545893

Maternal exome analysis for the diagnosis of oocyte maturation defects and early embryonic developmental arrest. Capalbo A, Buonaiuto S, Figliuzzi M, Damaggio G, Girardi L, Caroselli S, Poli M, Patassini C, Cetinkaya M, Yuksel B, Azad A, Grondahl M, Hoffmann E, Simon C, Colonna V, Kahraman S. Reproductive Biomedicine Online. 2022 Sep;45(3):508-518. doi: 10.1016/j.rbmo.2022.05.009. PMID: 35798635

Molecular Management of High-Grade Serous Ovarian Carcinoma. Punzon-Jimenez P, Lago V, Domingo S, Simon C, Mas A. International Journal of Molecular Sciences. 2022 Nov 9;23(22):13777. doi: 10.3390/ijms232213777. PMID: 36430255

Non-invasive preimplantation genetic testing for aneuploidies: an update. Navarro-Sanchez L, Garcia-Pascual C, Rubio C, Simon C. Reproductive Biomedicine Online. 2022 May;44(5):817-828. doi: 10.1016/j.rbmo.2022.01.012. PMID: 35307298

PGDIS position statement on the transfer of mosaic embryos 2021. Leigh D, Cram D, Rechitsky S, Handyside A, Wells D, Munne S, Kahraman S, Grifo J, Katz-Jaffe M, Rubio C, Viotti M, Forman E, Xu K, Gordon T, Madjunkova S, Qiao J, Chen Z, Harton G, Gianaroli L, Simon C, Scott R, Simpson J, Kuliev A. Reproductive Biomedicine Online. 2022 Jul;45(1):19-25. doi: 10.1016/j.rbmo.2022.03.013. PMID: 35523707

Should patients be screened for chronic endometritis before assisted reproductive technology?. Cicinelli E, McQueen DB, Huepfel B, Vitagliano A, Moreno I, Simon C, Pirtea P, Scott RTJ, Bellavia M, de Ziegler D. Fertility and Sterility. 2022 Oct;118(4):639-652. doi: 10.1016/j.fertnstert.2022.08.846. PMID: 36182261

The endometrial microbiome and its impact on human conception. Toson B, Simon C, Moreno I. International Journal of Molecular Sciences. 2022 Jan 1;23(1):485. doi: 10.3390/ijms23010485. PMID: 35008911

Bacterial Vaginosis and Its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease. Ravel J, Moreno Gimeno I, Simon Valles C. American Journal of Obstetrics and Gynecology. 2021 Mar;224(3):251-257. doi: 10.1016/j.ajog.2020.10.019. PMID: 33091407

BRCA, breast cancer and in vitro fertilization: how should we advise our patients?. Garcia-Planells J, Frances B, Diez-Juan A. Fertility and Sterility. 2021 Aug;116(2):359-360. doi: 10.1016/j.fertnstert.2021.06.011. PMID: 34247761

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population. Capalbo A, Fabiani M, Caroselli S, Poli M, Girardi L, Patassini C, Favero F, Cimadomo D, Vaiarelli A, Simon C, Rienzi LF, Ubaldi FM. Human Reproduction. 2021 Jun 18;36(7):2050-2061. doi: 10.1093/humrep/deab087. PMID: 34021342

Consensus vision. Simon C. Fertility and Sterility. 2021 Jul;116(1):13-14. doi: 10.1016/j.fertnstert.2021.05.090. PMID: 34148581

Darwin meets Mendel in the reproductive medicine field: Homo sapiens 2.0 is inevitable. O’Brien J, Adashi E, Simon C. Fertility and Sterility. 2021 Apr;115(4):850-851. doi: 10.1016/j.fertnstert.2021.01.047. PMID: 33642062

Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia. Garrido-Gomez T, Castillo-Marco N, Clemente-Ciscar M, Cordero T, Munoz-Blat I, Amadoz A, Jimenez-Almazan J, Monfort-Ortiz R, Climent R, Perales-Marin A, Simon C. eLife. 2021 Oct 28;10:e70753. doi: 10.7554/eLife.70753. PMID: 34709177

Embryo Genetics. Rubio C, Simon C. Genes. 2021 Jan 19;12(1):118. doi: 10.3390/genes12010118. PMID: 33477974

Endometrial factor in unexplained infertility and recurrent implantation failure. Santamaria X, Simon C. Seminars in Reproductive Medicine. 2021 Nov;39(5-06):227-232. doi: 10.1055/s-0041-1735199. PMID: 34425598

Invitro fertilization and andrology laboratories in 2030. Simon C, Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L. Fertility and Sterility. 2021 Jul;116(1):2-3. doi: 10.1016/j.fertnstert.2021.05.089. PMID: 34148585

Invitro fertilization and andrology laboratory in 2030: expert visions. Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L, Simon C. Fertility and Sterility. 2021 Jul;116(1):4-12. doi: 10.1016/j.fertnstert.2021.05.088. PMID: 34148588

Molecular and cellular insights into the development of uterine fibroids. Machado-Lopez A, Simon C, Mas A. International Journal of Molecular Sciences. 2021 Aug 6;22(16):8483. doi: 10.3390/ijms22168483. PMID: 34445194

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial. Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, Cimadomo D, Benini F, Farcomeni A, Cuzzi J, Rubio C, Albani E, Sacchi L, Vaiarelli A, Figliuzzi M, Findikli N, Coban O, Boynukalin FK, Vogel I, Hoffmann E, Livi C, Levi-Setti PE, Ubaldi FM, Simon C. American Journal of Human Genetics. 2021 Dec 2;108(12):2238-2247. doi: 10.1016/j.ajhg.2021.11.002. PMID: 34798051

Noninvasive preimplantation genetic testing for aneuploidy in spent blastocyst media will substitute for trophectoderm biopsy. Simon C. Fertility and sterility. 2021 Apr;115(4):840. doi: 10.1016/j.fertnstert.2021.02.046. PMID: 33726897

Noninvasive preimplantation genetic testing for aneuploidy in spent culture medium as a substitute for trophectoderm biopsy. Rubio C, Racowsky C, Barad D, Scott R, Simon C. Fertility and Sterility. 2021 Apr;115(4):841-849. doi: 10.1016/j.fertnstert.2021.02.045. PMID: 33741125

Noninvasive preimplantation genetic testing for aneuploidy: is the glass half-empty or half-full?. Rubio C, Simon C. Fertility and Sterility. 2021 Jun;115(6):1426-1427. doi: 10.1016/j.fertnstert.2021.04.002. PMID: 34053511

Obesity affects endometrial receptivity by displacing the window of implantation. Bellver J, Marin C, Lathi RB, Murugappan G, Labarta E, Vidal C, Giles J, Cabanillas S, Marzal A, Galliano D, Ruiz-Alonso M, Simon C, Valbuena D. Reproductive Sciences. 2021 Nov;28(11):3171-3180. doi: 10.1007/s43032-021-00631-1. PMID: 34033112

Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data. Capalbo A, Poli M, Riera-Escamilla A, Shukla V, Kudo Hoffding M, Krausz C, Hoffmann E, Simon Valles C. Human Reproduction Update. 2021 Feb 19;27(2):254-279. doi: 10.1093/humupd/dmaa044. PMID: 33197264

Response to: Comments on the methodology of an endometrial receptivity array trial. Simon C, Gomez C, Ruiz M, Mol B, Valbuena D. Reproductive Biomedicine Online. 2021 Jan;42(1):284. doi: 10.1016/j.rbmo.2020.09.028. PMID: 33060012

SARS-CoV-2 immunity, infective and naïve incidence in fertility clinics after lockdown. Foulk R, Sakkas D, Kayali R, Valbuena D, Simon C, Cuzzi J. American Journal of Obstetrics and Gynecology.2021 Jul;225(1):103-105. doi: 10.1016/j.ajog.2021.03.008. PMID: 33716073

Should vanishing twin pregnancies be systematically excluded from cell-free fetal DNA testing?. Balaguer N, Mateu Brull E, Serra V, Simon C, Milan M. Prenatal Diagnosis. 2021 Sep;41(10):1241-1248. doi: 10.1002/pd.5817. PMID: 32835421

Single-cell RNA Sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium. Vilella F, Wang W, Moreno I, Roson B, Quake S, Simon C. Human Reproduction. 2021 Sep 18;36(10):2709-2719. doi: 10.1093/humrep/deab183. PMID: 34329437

Sperm DNA methylation epimutation biomarker for paternal offspring autism susceptibility. Garrido N, Cruz F, Egea R, Simon C, Sadler-Riggleman I, Beck D, Nilsson E, Ben Maamar M, Skinner M. Clinical Epigenetics. 2021 Jan 7;13(1):6. doi: 10.1186/s13148-020-00995-2. PMID: 33413568

Understanding the human endometrium in the 21st century. Vilella F, Wang W, Moreno I, Quake SR, Simon C. American Journal of Obstetrics and Gynecology. 2021 Jul;225(1):1-2. doi: 10.1016/j.ajog.2021.04.224. PMID: 34023092

Projects
Reference: PI21/00235
Title: Estudio del impacto del microbioma endometrial sobre el endometrio humano en condiciones fisiológicas y patológicas a nivel de célula única
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Inmaculada Moreno Gimeno
Duration: 2022 – 2024
Total budget: 169.279 €
Reference: PI20/00942
Title: Desarrollo de un modelo predictivo para el diagnóstico diferencial temprano de leiomiomas y leiomiosarcomas uterinos
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Aymara Mas Perucho
Duration: 2021 – 2023
Total budget: 99.825 €
Reference: PI-2021-010
Title: CellStats: Desarrollo de un modelo estadístico para la evaluación de cambios poblacionales en datos transcriptómicos de célula única del endometrio humano
Funding body: Universidad de Valencia – INCLIVA
Principal Investigator: Guillermo Ayala Gallego, Beatriz Rosón Burgo
Duration: 2021 – 2022
Total budget: 16.150 €
Reference: 874867 – HUTER
Title: Human Uterus Cell Atlas
Funding body: European Commission
Principal Investigator: Carlos Simón Vallés
Duration: 2020 – 2022
Total budget: 4.118.943 €
Reference: PI19/01659
Title: Análisis transcriptómico a nivel de célula única y tejido endometrial completo del fallo en decidualización presente en pacientes con preclampsia severa
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Tamara Garrido Gómez
Duration: 2020 – 2022
Total budget: 93.170 €
Reference: RTI2018-094946-B-I00
Title: Contribución materna en la patogénesis de enfermedades gestacionales tardías como la preeclampsia
Funding body: Ministerio de Ciencia, Innovación y Universidades
Principal Investigator: Carlos Simón Vallés
Duration: 2019 – 2022
Total budget: 254.100 €
Reference: PROMETEO/2018/161
Title: Medicina regenerativa del útero humano: desde la terapia celular a la creación del órgano mediante bioingeniería
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Carlos Simón Vallés
Duration: 2018 – 2021
Total budget: 297.066 €
Reference: BFU 2015-72131-EXP
Title: Criptocromos, la inexplicable presencia de sensores de luz en la oscuridad que conectan el embrión temprano con el cosmos
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Carlos Simón Vallés
Duration: 2017 – 2019
Total budget: 60.000 €
+ Info
Title: Molecular investigation on the etiology of preeclampsia and new strategies for its early diagnosis
Doctoral candidate: Castillo Marco, Nerea
Director(s): Simón Vallés, Carlos; Garrigo Gómez Tamara
Date of the defense: 20/06/2023
University: University de Valencia

Title: Analysis of the endometrial microbiome and its impact on human reproduction
Doctoral candidate: García Grau, Iolanda
Director(s): Simón Vallés, Carlos; Moreno Gimeno, Inmaculada; Remohí Giménez, Jose
Date of the defense: 11/06/2021
University: Universitat de València

Title: Decidualización defectuosa durante y después de un embarazo con preeclampsia revela la contribución materna en la etiología de la enfermedad
Doctoral candidate: Rubert Torró, Laura
Director(s): Perales Marín, Alfredo; Simón Vallés, Carlos; Garrido Gómez, Tamara
Date of the defense: 08/02/2021
University: Universitat de València

Title: Extracellular vesicles in the human maternal-embryo crosstalk during the preconception period
Doctoral candidate: Bolumar Recuero, David
Director(s): Simón Vallés, Carlos; Vilella Mitjana, Felipe
Date of the defense: 21/12/2020
University: Universitat de València

Title: Epigenetic analysis of cell-free dna as a tool to study pathogenesis and maternal syndrome of preeclampsia
Doctoral candidate: Corachán García, Irene
Director(s): Simón Vallés, Carlos; Díez Juan, Antonio; Vilella Mitjana, Felipe
Date of the defense: 14/02/2020
University: Universitat de València

Title: Maternal-fetal crosstalk. Elucitaing the role of mir30d in endometrial receptivity and pregnancy outcome
Doctoral candidate: Balaguer Cuenca, Nuria
Director(s): Vilella Mitjana, Felipe; Simón Vallés, Carlos
Date of the defense: 14/01/2019
University: Universitat de València